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• Introduction of SysPIMP
• Structure of SysPIMP
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• OMIM Mutated Sequence Browser
• OMIM Classification

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• Human Genomes
• Integrated annotated Human normal Protein Browser
• IHP Statistics
• Integrated Mutated Sequence Browser
• Chromosomal Distribution
• IMS Statistics

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Integrated annotated Human normal Protein (IHP) Browser

Detalied information of IHP

Name

ENSP00000248975

Comment

Origin of IHP Origin Name Protein Mutation Database A020095 Protein Mutation Database C024115 Human genome (Ensembl) ENSP00000361585 Human genome (Celera Assembly, NCBI) NP_003396.1 Human genome (HuRef Assembly, NCBI) NP_003396.1 Human genome (Reference Genome, NCBI) NP_003396.1 SwissProt proteins Q9Y3L3 MSIPI IPI00215617.1

Gene Origins Genename Origins YWHAH Human genome (Celera Assembly, NCBI) Human genome (HuRef Assembly, NCBI) Human genome (Reference Genome, NCBI) SwissProt proteins MSIPI Genenames in OMIM Genemap 1433F_HUMAN SwissProt proteins YWHA1 Genenames in OMIM Genemap 1433F Genenames as removing '_HUMAN'

Interpro Annotation

IPR000308 (12.00): 14-3-3 protein (1~84) (85~117) (118~152) (153~246)
noIPR (12.00): (2~246)
IPR000308 (18.00): 14-3-3 protein (1~215) (216~246)
noIPR (18.00): (9~236)

6 Mutated sequence(s)

Name	Length (aa)	Type
IMS043194	246	Point ,Point
IMS168674	246	Point
IMS168675	246	Point
IMS168676	246	Point
IMS168677	246	Point
IMS168678	246	Point

Amino acid length

246 aa

Amino acid sequence viewer

	|......10|.......20|.......30|.......40|.......50|.......60|.......70|.......80|
+ 1 81 161 241	MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTMADGNEKKLE KVKAYREKIEKELETVCNDVLSLLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEI SKEQMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDE EAGEGN

cDNA sequence length

1792 bp

cDNA sequence viewer

|......10|.......20|.......30|.......40|.......50|.......60|.......70|.......80|

+ 1 81 161 241 321 401 481 561 641 721 801 881 961 1041 1121 1201 1281 1361 1441 1521 1601 1681 1761

GCGGCCGCGTCTCCTCCCTCGGCGTTGTCCGCGGCGCGAGCCACAGCGCGCGGGGCGAGCCAGCGAGAGGGCGCGAGCGG CGGCGCTGCCTGCAGCCTGCAGCCTGCAGCCTCCGGCCGGCCGGCGAGCCAGTGCGCGTGCGCGGCGGCGGCCTCCGCAG CGACCGGGGAGCGGACTGACCGGCGGGAGGGCTAGCGAGCCAGCGGTGTGAGGCGCGAGGCGAGGCCGAGCCGCGAGCGA CATGGGGGACCGGGAGCAGCTGCTGCAGCGGGCGCGGCTGGCCGAGCAGGCGGAGCGCTACGACGACATGGCCTCCGCTA TGAAGGCGGTGACAGAGCTGAATGAACCTCTCTCCAATGAAGATCGAAATCTCCTCTCTGTGGCCTACAAGAATGTGGTT GGTGCCAGGCGATCTTCCTGGAGGGTCATTAGCAGCATTGAGCAGAAAACCATGGCTGATGGAAACGAAAAGAAATTGGA GAAAGTTAAAGCTTACCGGGAGAAGATTGAGAAGGAGCTGGAGACAGTTTGCAATGATGTCCTGTCTCTGCTTGACAAGT TCCTGATCAAGAACTGCAATGATTTCCAGTATGAGAGCAAGGTGTTTTACCTGAAAATGAAGGGTGATTACTACCGCTAC TTAGCAGAGGTCGCTTCTGGGGAGAAGAAAAACAGTGTGGTCGAAGCTTCTGAAGCTGCCTACAAGGAAGCCTTTGAAAT CAGCAAAGAGCAGATGCAACCCACGCATCCCATCCGGCTGGGCCTGGCCCTCAACTTCTCCGTGTTCTACTATGAGATCC AGAATGCACCTGAGCAAGCCTGCCTCTTAGCCAAACAAGCCTTCGATGATGCCATAGCTGAGCTGGACACACTAAACGAG GATTCCTATAAGGACTCCACGCTGATCATGCAGTTGCTGCGAGACAACCTCACCCTCTGGACGAGCGACCAGCAGGATGA AGAAGCAGGAGAAGGCAACTGAAGATCCTTCAGGTCCCCTGGCCCTTCCTTCACCCACCACCCCCATCATCACCGATTCT TCCTTGCCACAATCACTAAATATCTAGTGCTAAACCTATCTGTATTGGCAGCACAGCTACTCAGATCTGCACTCCTGTCT CTTGGGAAGCAGTTTCAGATAAATCATGGGCATTGCTGGACTGATGGTTGCTTTGAGCCCACAGGAGCTCCCTTTTTGAA TTGTGTGGAGAAGTGTGTTCTGATGAGGCATTTTACTATGCCTGTTGATCTATGGGAAATCTAGGCGAAAGTAATGGGGA AGATTAGAAAGAATTAGCCAACCAGGCTACAGTTGATATTTAAAAGATCCATTTAAAACAAGCTGATAGTGTTTCGTTAA GCAGTACATCTTGTGCATGCAAAAATGAATTCACCCCTCCCACCTCTTTCTTCAATTAATGGAAAACTGTTAAGGGAAGC TGATACAGAGAGACAACTTGCTCCTTTCCATCAGCTTTATAATAAACTGTTTAACGTGAGGTTTCAGTAGCTCCTTGGTT TTGCCTCTTTAAATTATGACGTGCACAAACCTTCTTTTCAATGCAATGCATCTGAAAGTTTTGATACTTGTAACTTTTTT TTTTTTTTGGTTGCAATTGTTTAAGAATCATGGATTTATTTTTTGTAACTCTTTGGCTATTGTCCTTGTGTATCCTGACA GCGCCATGTGTGTCAGCCCATGTCAATCAAGATGGGTGATTATGAAATGCCAGACTTCTAAAATAAATGTTTTGGAATTC AATGGGTAAATAAATGCTGCTTTGGGGATATT

Codon usage

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

M

G

D

R

E

Q

L

L

Q

R

A

R

L

A

E

GCG

GCC

GCG

TCT

CCT

CCC

TCG

GCG

TTG

TCC

GCG

GCG

CGA

GCC

ACA

16

17

18

19

20

21

22

23

24

25

26

27

28

29

30

Q

A

E

R

Y

D

D

M

A

S

A

M

K

A

V

GCG

CGC

GGG

GCG

AGC

CAG

CGA

GAG

GGC

GCG

AGC

GGC

GGC

GCT

GCC

31

32

33

34

35

36

37

38

39

40

41

42

43

44

45

T

E

L

N

E

P

L

S

N

E

D

R

N

L

L

TGC

AGC

CTG

CAG

CCT

GCA

GCC

TCC

GGC

CGG

CCG

GCG

AGC

CAG

TGC

46

47

48

49

50

51

52

53

54

55

56

57

58

59

60

S

V

A

Y

K

N

V

V

G

A

R

R

S

S

W

GCG

TGC

GCG

GCG

GCG

GCC

TCC

GCA

GCG

ACC

GGG

GAG

CGG

ACT

GAC

61

62

63

64

65

66

67

68

69

70

71

72

73

74

75

R

V

I

S

S

I

E

Q

K

T

M

A

D

G

N

CGG

CGG

GAG

GGC

TAG

CGA

GCC

AGC

GGT

GTG

AGG

CGC

GAG

GCG

AGG

76

77

78

79

80

81

82

83

84

85

86

87

88

89

90

E

K

K

L

E

K

V

K

A

Y

R

E

K

I

E

CCG

AGC

CGC

GAG

CGA

CAT

GGG

GGA

CCG

GGA

GCA

GCT

GCT

GCA

GCG

91

92

93

94

95

96

97

98

99

100

101

102

103

104

105

K

E

L

E

T

V

C

N

D

V

L

S

L

L

D

GGC

GCG

GCT

GGC

CGA

GCA

GGC

GGA

GCG

CTA

CGA

CGA

CAT

GGC

CTC

106

107

108

109

110

111

112

113

114

115

116

117

118

119

120

K

F

L

I

K

N

C

N

D

F

Q

Y

E

S

K

CGC

TAT

GAA

GGC

GGT

GAC

AGA

GCT

GAA

TGA

ACC

TCT

CTC

CAA

TGA

121

122

123

124

125

126

127

128

129

130

131

132

133

134

135

V

F

Y

L

K

M

K

G

D

Y

Y

R

Y

L

A

AGA

TCG

AAA

TCT

CCT

CTC

TGT

GGC

CTA

CAA

GAA

TGT

GGT

TGG

TGC

136

137

138

139

140

141

142

143

144

145

146

147

148

149

150

E

V

A

S

G

E

K

K

N

S

V

V

E

A

S

CAG

GCG

ATC

TTC

CTG

GAG

GGT

CAT

TAG

CAG

CAT

TGA

GCA

GAA

AAC

151

152

153

154

155

156

157

158

159

160

161

162

163

164

165

E

A

A

Y

K

E

A

F

E

I

S

K

E

Q

M

CAT

GGC

TGA

TGG

AAA

CGA

AAA

GAA

ATT

GGA

GAA

AGT

TAA

AGC

TTA

166

167

168

169

170

171

172

173

174

175

176

177

178

179

180

Q

P

T

H

P

I

R

L

G

L

A

L

N

F

S

CCG

GGA

GAA

GAT

TGA

GAA

GGA

GCT

GGA

GAC

AGT

TTG

CAA

TGA

TGT

181

182

183

184

185

186

187

188

189

190

191

192

193

194

195

V

F

Y

Y

E

I

Q

N

A

P

E

Q

A

C

L

CCT

GTC

TCT

GCT

TGA

CAA

GTT

CCT

GAT

CAA

GAA

CTG

CAA

TGA

TTT

196

197

198

199

200

201

202

203

204

205

206

207

208

209

210

L

A

K

Q

A

F

D

D

A

I

A

E

L

D

T

CCA

GTA

TGA

GAG

CAA

GGT

GTT

TTA

CCT

GAA

AAT

GAA

GGG

TGA

TTA

211

212

213

214

215

216

217

218

219

220

221

222

223

224

225

L

N

E

D

S

Y

K

D

S

T

L

I

M

Q

L

CTA

CCG

CTA

CTT

AGC

AGA

GGT

CGC

TTC

TGG

GGA

GAA

GAA

AAA

CAG

226

227

228

229

230

231

232

233

234

235

236

237

238

239

240

L

R

D

N

L

T

L

W

T

S

D

Q

Q

D

E

TGT

GGT

CGA

AGC

TTC

TGA

AGC

TGC

CTA

CAA

GGA

AGC

CTT

TGA

AAT

241

242

243

244

245

246

E

A

G

E

G

N

CAG

CAA

AGA

GCA

GAT

GCA

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