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Integrated annotated Human normal Protein (IHP) Browser

Detalied information of IHP

Name

ENSP00000261008

Comment

Origin of IHP Origin Name Protein Mutation Database C023539 Protein Mutation Database A900608 Protein Mutation Database A910502 Protein Mutation Database C962076 Human genome (Ensembl) ENSP00000368121 Human genome (Celera Assembly, NCBI) NP_000070.1 Human genome (HuRef Assembly, NCBI) NP_000070.1 Human genome (Reference Genome, NCBI) NP_000070.1 SwissProt isoform proteins Q9H553-2 MSIPI IPI00217470.1

Gene Origins Genename Origins CHRNA1 Human genome (Celera Assembly, NCBI) Human genome (HuRef Assembly, NCBI) Human genome (Reference Genome, NCBI) SwissProt isoform proteins MSIPI Genenames in OMIM Genemap Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt ACHA_HUMAN SwissProt isoform proteins Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt ACHRA SwissProt isoform proteins Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt ACHRD Genenames in OMIM Genemap Genenames in OMIM Genemap Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt CMS2A Genenames in OMIM Genemap Genenames in OMIM Genemap Genenames in OMIM Genemap Genenames in OMIM Genemap SCCMS Genenames in OMIM Genemap Genenames in OMIM Genemap Genenames in OMIM Genemap Genenames in OMIM Genemap FCCMS Genenames in OMIM Genemap Genenames in OMIM Genemap Genenames in OMIM Genemap CHRND Genenames in OMIM Genemap Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt CHRNE Genenames in OMIM Genemap Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt CMS1E Genenames in OMIM Genemap CMS1D Genenames in OMIM Genemap Genenames in OMIM Genemap CHRNB1 Genenames in OMIM Genemap Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt ACHRB Genenames in OMIM Genemap Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt ACHA Genenames as removing '_HUMAN' ACHB_HUMAN Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt ACHD_HUMAN Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt ACHE_HUMAN Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt ACHRE Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt Mapping OMIM mutations to SwissProt

Interpro Annotation

IPR002394 (12.00): Nicotinic acetylcholine receptor (58~73) (92~105) (110~121) (128~146)
IPR006029 (12.00): Neurotransmitter-gated ion-channel transmembrane region (238~446)
IPR006201 (12.00): Neurotransmitter-gated ion-channel (1~103) (104~147) (148~224) (225~457)
IPR006202 (12.00): Neurotransmitter-gated ion-channel ligand-binding (22~231)
IPR006029 (18.00): Neurotransmitter-gated ion-channel transmembrane region (231~457)
IPR006201 (18.00): Neurotransmitter-gated ion-channel (1~455)
IPR006202 (18.00): Neurotransmitter-gated ion-channel ligand-binding (22~236)
noIPR (18.00): (6~18) (41~302) (303~455)

10 Mutated sequence(s)

Name	Length (aa)	Type
IMS046989	457	Point
IMS046988	457	Point
IMS000011	457	Point
IMS000014	457	Point
IMS171253	457	Point
IMS171254	457	Point
IMS171255	457	Point
IMS046987	456	Deletion ,Point
IMS015832	457	Point
IMS000003	15	Deletion

Amino acid length

457 aa

Amino acid sequence viewer

|......10|.......20|.......30|.......40|.......50|.......60|.......70|.......80|

+ 1 81 161 241 321 401

MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQW VDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQ NCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVII PCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHH RSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIK YIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG

cDNA sequence length

1960 bp

cDNA sequence viewer

|......10|.......20|.......30|.......40|.......50|.......60|.......70|.......80|

+ 1 81 161 241 321 401 481 561 641 721 801 881 961 1041 1121 1201 1281 1361 1441 1521 1601 1681 1761 1841 1921

AGTGAGAAGCACAGGCCACCACTCTGCCCTGGTCCACACAAGCTCCGGTAGCCCATGGAGCCCTGGCCTCTCCTCCTGCT CTTTAGCCTTTGCTCAGGTAAGCTCGTCCTGGGCTCCGAACATGAGACCCGTCTGGTGGCAAAGCTATTTAAAGACTACA GCAGCGTGGTGCGGCCAGTGGAAGACCACCGCCAGGTCGTGGAGGTCACCGTGGGCCTGCAGCTGATACAGCTCATCAAT GTGGTGAGAGTAAATCAGATCGTGACAACCAATGTGCGTCTGAAACAGGTAACGGTGGATTACAACCTAAAATGGAATCC AGATGACTATGGCGGTGTGAAAAAAATTCACATTCCTTCAGAAAAGATCTGGCGCCCAGACCTTGTTCTCTATAACAAGT GAGATGGTGACTTTGCTATTGTCAAGTTCACCAAAGTGCTCCTGCAGTACACTGGCCACATCACGTGGACACCTCCAGCC ATCTTTAAAAGCTACTGTGAGATCATCGTCACCCACTTTCCCTTTGATGAACAGAACTGCAGCATGAAGCTGGGCACCTG GACCTACGACGGCTCTGTCGTGGCCATCAACCCGGTAGGCGACCAGCCAGACCTGAGCAACTTCATGGAGAGCGGGGAGT GGGTGATCAAGGAGTCCCGGGGCTGGAAGCACTCCGTGACCTATTCCTGCTGCCCCGACACCCCCTACCTGGACATCACC TACCACTTCGTCATGCAGCGCCTGCCCCTCTACTTCATCGTCAACGTCATCATCCCCTGCCTGCTCTTCTCCTTCTTAAC TGGCCTGGTATTCTACCTGCCCACAGACTCAGGTGGGAAGATGACTCTGAGCATCTCTGTCTTACTGTCTTTGACTGTGT TCCTTCTGGTCATCGTGGAGCTGATCCCCTCCACGTCCAGTGCTGTGCCCTTGATTGGAAAATACATGCTGTTCACCATG GTGTTCGTCATTGCCTCCATCATCATCACTGTCATCGTCATCAACACACACCACCGCTCACCCAGCACCCATGTCATGCC CAACTGGGTGCGGAAGGTGAGTATCGACACTATCCCAAATATCATGTTTTTCTCCACAATGAAAAGACCATCCAGAGAAA AGCAAGACAAAAAGATTTTTACAGAAGACATTGATATCTCTGACATTTCTGGAAAGCCAGGGCCTCCACCCATGGGCTTC CACTCTCCCCTGATCAAACACCCCGAGGTGAAAAGTGCCATCGAGGGCATCAAGTACATCGCAGAGACCATGAAGTCAGA CCAGGAGTCTAACAATGTAAGGGCAGAGTGGAAGTACGTTGCAATGGTGATGGACCACATACTCCTCGGAGTCTTCATGC TTGTTTGCATCATCGGAACCCTAGCCGTGTTTGCAGGTCGACTCATTGAATTAAATCAGCAAGGATGAGCAGAAAATGAG CTGAGCTTAGCTCTGCCCTGGAACCTACCAGAGCAGAGAAGGGCAGGAGAGGAAGATTTGTCTACTTGCTCCACTCGCAC TTATCAAACGTGTTATATTCCATACTTATTATTGATGATAAGATTTACCTTTATGTAAGTTTATGGCCTTGAAGTGTTTT CATATTGCTTCTCCCTTTAGTTCTGCTGTCTCCCTGAAGAGTGAACCCTCTTTAGTAAATGAAACTAATCACTAAAAAAA GTGTTCATTTCCAGTGTCTGGAAGAGTTTTTGCCAGGATAACCGAGGTTTTCTGTTGCATTGTCATTGCTGTTATATTTA TATATTTACTTATTTTGTCTAACCACGAGACCACTAGGGAGTTGCTGATGTTCTAAATGAAGTGTATTCTTTGCTTAAGA GTCAGTTTTGTACCTACTAAGAAAACCCCATCTACCAGTCCTAAAGAGATAAGGCATTTGATTTGGAGAGAGAGGAAGCA GTAGAAATGAAATAAACTAAAATGCAAACTGCATCAAAAA

Codon usage

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

M

E

P

W

P

L

L

L

L

F

S

L

C

S

A

AGT

GAG

AAG

CAC

AGG

CCA

CCA

CTC

TGC

CCT

GGT

CCA

CAC

AAG

CTC

16

17

18

19

20

21

22

23

24

25

26

27

28

29

30

G

L

V

L

G

S

E

H

E

T

R

L

V

A

K

CGG

TAG

CCC

ATG

GAG

CCC

TGG

CCT

CTC

CTC

CTG

CTC

TTT

AGC

CTT

31

32

33

34

35

36

37

38

39

40

41

42

43

44

45

L

F

K

D

Y

S

S

V

V

R

P

V

E

D

H

TGC

TCA

GGT

AAG

CTC

GTC

CTG

GGC

TCC

GAA

CAT

GAG

ACC

CGT

CTG

46

47

48

49

50

51

52

53

54

55

56

57

58

59

60

R

Q

V

V

E

V

T

V

G

L

Q

L

I

Q

L

GTG

GCA

AAG

CTA

TTT

AAA

GAC

TAC

AGC

AGC

GTG

GTG

CGG

CCA

GTG

61

62

63

64

65

66

67

68

69

70

71

72

73

74

75

I

N

V

D

E

V

N

Q

I

V

T

T

N

V

R

GAA

GAC

CAC

CGC

CAG

GTC

GTG

GAG

GTC

ACC

GTG

GGC

CTG

CAG

CTG

76

77

78

79

80

81

82

83

84

85

86

87

88

89

90

L

K

Q

Q

W

V

D

Y

N

L

K

W

N

P

D

ATA

CAG

CTC

ATC

AAT

GTG

GTG

AGA

GTA

AAT

CAG

ATC

GTG

ACA

ACC

91

92

93

94

95

96

97

98

99

100

101

102

103

104

105

D

Y

G

G

V

K

K

I

H

I

P

S

E

K

I

AAT

GTG

CGT

CTG

AAA

CAG

GTA

ACG

GTG

GAT

TAC

AAC

CTA

AAA

TGG

106

107

108

109

110

111

112

113

114

115

116

117

118

119

120

W

R

P

D

L

V

L

Y

N

N

A

D

G

D

F

AAT

CCA

GAT

GAC

TAT

GGC

GGT

GTG

AAA

AAA

ATT

CAC

ATT

CCT

TCA

121

122

123

124

125

126

127

128

129

130

131

132

133

134

135

A

I

V

K

F

T

K

V

L

L

Q

Y

T

G

H

GAA

AAG

ATC

TGG

CGC

CCA

GAC

CTT

GTT

CTC

TAT

AAC

AAG

TGA

GAT

136

137

138

139

140

141

142

143

144

145

146

147

148

149

150

I

T

W

T

P

P

A

I

F

K

S

Y

C

E

I

GGT

GAC

TTT

GCT

ATT

GTC

AAG

TTC

ACC

AAA

GTG

CTC

CTG

CAG

TAC

151

152

153

154

155

156

157

158

159

160

161

162

163

164

165

I

V

T

H

F

P

F

D

E

Q

N

C

S

M

K

ACT

GGC

CAC

ATC

ACG

TGG

ACA

CCT

CCA

GCC

ATC

TTT

AAA

AGC

TAC

166

167

168

169

170

171

172

173

174

175

176

177

178

179

180

L

G

T

W

T

Y

D

G

S

V

V

A

I

N

P

TGT

GAG

ATC

ATC

GTC

ACC

CAC

TTT

CCC

TTT

GAT

GAA

CAG

AAC

TGC

181

182

183

184

185

186

187

188

189

190

191

192

193

194

195

E

S

D

Q

P

D

L

S

N

F

M

E

S

G

E

AGC

ATG

AAG

CTG

GGC

ACC

TGG

ACC

TAC

GAC

GGC

TCT

GTC

GTG

GCC

196

197

198

199

200

201

202

203

204

205

206

207

208

209

210

W

V

I

K

E

S

R

G

W

K

H

S

V

T

Y

ATC

AAC

CCG

GTA

GGC

GAC

CAG

CCA

GAC

CTG

AGC

AAC

TTC

ATG

GAG

211

212

213

214

215

216

217

218

219

220

221

222

223

224

225

S

C

C

P

D

T

P

Y

L

D

I

T

Y

H

F

AGC

GGG

GAG

TGG

GTG

ATC

AAG

GAG

TCC

CGG

GGC

TGG

AAG

CAC

TCC

226

227

228

229

230

231

232

233

234

235

236

237

238

239

240

V

M

Q

R

L

P

L

Y

F

I

V

N

V

I

I

GTG

ACC

TAT

TCC

TGC

TGC

CCC

GAC

ACC

CCC

TAC

CTG

GAC

ATC

ACC

241

242

243

244

245

246

247

248

249

250

251

252

253

254

255

P

C

L

L

F

S

F

L

T

G

L

V

F

Y

L

TAC

CAC

TTC

GTC

ATG

CAG

CGC

CTG

CCC

CTC

TAC

TTC

ATC

GTC

AAC

256

257

258

259

260

261

262

263

264

265

266

267

268

269

270

P

T

D

S

G

E

K

M

T

L

S

I

S

V

L

GTC

ATC

ATC

CCC

TGC

CTG

CTC

TTC

TCC

TTC

TTA

ACT

GGC

CTG

GTA

271

272

273

274

275

276

277

278

279

280

281

282

283

284

285

L

S

L

T

V

F

L

L

V

I

V

E

L

I

P

TTC

TAC

CTG

CCC

ACA

GAC

TCA

GGT

GGG

AAG

ATG

ACT

CTG

AGC

ATC

286

287

288

289

290

291

292

293

294

295

296

297

298

299

300

S

T

S

S

A

V

P

L

I

G

K

Y

M

L

F

TCT

GTC

TTA

CTG

TCT

TTG

ACT

GTG

TTC

CTT

CTG

GTC

ATC

GTG

GAG

301

302

303

304

305

306

307

308

309

310

311

312

313

314

315

T

M

V

F

V

I

A

S

I

I

I

T

V

I

V

CTG

ATC

CCC

TCC

ACG

TCC

AGT

GCT

GTG

CCC

TTG

ATT

GGA

AAA

TAC

316

317

318

319

320

321

322

323

324

325

326

327

328

329

330

I

N

T

H

H

R

S

P

S

T

H

V

M

P

N

ATG

CTG

TTC

ACC

ATG

GTG

TTC

GTC

ATT

GCC

TCC

ATC

ATC

ATC

ACT

331

332

333

334

335

336

337

338

339

340

341

342

343

344

345

W

V

R

K

V

F

I

D

T

I

P

N

I

M

F

GTC

ATC

GTC

ATC

AAC

ACA

CAC

CAC

CGC

TCA

CCC

AGC

ACC

CAT

GTC

346

347

348

349

350

351

352

353

354

355

356

357

358

359

360

F

S

T

M

K

R

P

S

R

E

K

Q

D

K

K

ATG

CCC

AAC

TGG

GTG

CGG

AAG

GTG

AGT

ATC

GAC

ACT

ATC

CCA

AAT

361

362

363

364

365

366

367

368

369

370

371

372

373

374

375

I

F

T

E

D

I

D

I

S

D

I

S

G

K

P

ATC

ATG

TTT

TTC

TCC

ACA

ATG

AAA

AGA

CCA

TCC

AGA

GAA

AAG

CAA

376

377

378

379

380

381

382

383

384

385

386

387

388

389

390

G

P

P

P

M

G

F

H

S

P

L

I

K

H

P

GAC

AAA

AAG

ATT

TTT

ACA

GAA

GAC

ATT

GAT

ATC

TCT

GAC

ATT

TCT

391

392

393

394

395

396

397

398

399

400

401

402

403

404

405

E

V

K

S

A

I

E

G

I

K

Y

I

A

E

T

GGA

AAG

CCA

GGG

CCT

CCA

CCC

ATG

GGC

TTC

CAC

TCT

CCC

CTG

ATC

406

407

408

409

410

411

412

413

414

415

416

417

418

419

420

M

K

S

D

Q

E

S

N

N

A

A

A

E

W

K

AAA

CAC

CCC

GAG

GTG

AAA

AGT

GCC

ATC

GAG

GGC

ATC

AAG

TAC

ATC

421

422

423

424

425

426

427

428

429

430

431

432

433

434

435

Y

V

A

M

V

M

D

H

I

L

L

G

V

F

M

GCA

GAG

ACC

ATG

AAG

TCA

GAC

CAG

GAG

TCT

AAC

AAT

GTA

AGG

GCA

436

437

438

439

440

441

442

443

444

445

446

447

448

449

450

L

V

C

I

I

G

T

L

A

V

F

A

G

R

L

GAG

TGG

AAG

TAC

GTT

GCA

ATG

GTG

ATG

GAC

CAC

ATA

CTC

CTC

GGA

451

452

453

454

455

456

457

I

E

L

N

Q

Q

G

GTC

TTC

ATG

CTT

GTT

TGC

ATC

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