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• Introduction of SysPIMP
• Structure of SysPIMP
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• OMIM Mutated Sequence Browser
• OMIM Classification

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• Human Genomes
• Integrated annotated Human normal Protein Browser
• IHP Statistics
• Integrated Mutated Sequence Browser
• Chromosomal Distribution
• IMS Statistics

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Integrated annotated Human normal Protein (IHP) Browser

Detalied information of IHP

Name

ENSP00000264335

Comment

Origin of IHP Origin Name Protein Mutation Database A005346 Protein Mutation Database A020096 Protein Mutation Database C030103 Human genome (Ensembl) ENSP00000307314 Human genome (Celera Assembly, NCBI) NP_006752.1 Human genome (HuRef Assembly, NCBI) NP_006752.1 Human genome (Reference Genome, NCBI) NP_006752.1 SwissProt proteins P06340 MSIPI IPI00000794.1

Gene Origins Genename Origins YWHAE Human genome (Celera Assembly, NCBI) Human genome (HuRef Assembly, NCBI) Human genome (Reference Genome, NCBI) SwissProt proteins MSIPI Genenames in OMIM Genemap 1433E_HUMAN SwissProt proteins MDCR Genenames in OMIM Genemap MDS Genenames in OMIM Genemap 1433E Genenames as removing '_HUMAN'

Interpro Annotation

IPR000308 (12.00): 14-3-3 protein (1~84) (85~115) (116~150) (151~255)
noIPR (12.00): (2~255)
IPR000308 (18.00): 14-3-3 protein (1~213) (214~248)

15 Mutated sequence(s)

Name	Length (aa)	Type
IMS029936	255	Point
IMS043195	255	Point
IMS043196	214	Deletion
IMS043197	232	Deletion
IMS043198	214	Point ,Deletion
IMS043199	232	Point ,Deletion
IMS043200	255	Point
IMS043201	255	Others
IMS043202	255	Others ,Point
IMS043203	255	Others ,Others
IMS043204	255	Others ,Others ,Point
IMS043205	255	Others ,Others ,Point ,Point
IMS121168	255	Point
IMS121169	255	Point
IMS121170	255	Point

Amino acid length

255 aa

Amino acid sequence viewer

	|......10|.......20|.......30|.......40|.......50|.......60|.......70|.......80|
+ 1 81 161 241	MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLK MIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAM TELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGE EQNKEALQDVEDENQ

cDNA sequence length

1777 bp

cDNA sequence viewer

|......10|.......20|.......30|.......40|.......50|.......60|.......70|.......80|

+ 1 81 161 241 321 401 481 561 641 721 801 881 961 1041 1121 1201 1281 1361 1441 1521 1601 1681 1761

CGGATTGAGGCGCCGCCATTTTTGCTGCCCGGACGCGGAGCGAGAGGCTGAGAGAGTCGGAGACACTATCCGCTTCCATC CGTCGCGCAGACCCTGCCGGAGCCGCTGCCGCTATGGATGATCGAGAGGATCTGGTGTACCAGGCGAAGCTGGCCGAGCA GGCTGAGCGATACGACGAAATGGTGGAGTCAATGAAGAAAGTAGCAGGGATGGATGTGGAGCTGACAGTTGAAGAAAGAA ACCTCCTATCTGTTGCATATAAGAATGTGATTGGAGCTAGAAGAGCCTCCTGGAGAATAATCAGCAGCATTGAACAGAAA GAAGAAAACAAGGGAGGAGAAGACAAGCTAAAAATGATTCGGGAATATCGGCAAATGGTTGAGACTGAGCTAAAGTTAAT CTGTTGTGACATTCTGGATGTACTGGACAAACACCTCATTCCAGCAGCTAACACTGGCGAGTCCAAGGTTTTCTATTATA AAATGAAAGGGGACTACCACAGGTATCTGGCAGAATTTGCCACAGGAAACGACAGGAAGGAGGCTGCGGAGAACAGCCTA GTGGCTTATAAAGCTGCTAGTGATATTGCAATGACAGAACTTCCACCAACGCATCCTATTCGCTTAGGTCTTGCTCTCAA TTTTTCCGTATTCTACTACGAAATTCTTAATTCCCCTGACCGTGCCTGCAGGTTGGCAAAAGCAGCTTTTGATGATGCAA TTGCAGAACTGGATACGCTGAGTGAAGAAAGCTATAAGGACTCTACACTTATCATGCAGTTGTTACGTGATAATCTGACA CTATGGACTTCAGACATGCAGGGTGACGGTGAAGAGCAGAATAAAGAAGCGCTGCAGGACGTGGAAGACGAAAATCAGTG AGACATAAGCCAACAAGAGAAACCATCTCTGACCACCCCCTCCTCCCCATCCCACCCTTTGGAAACTCCCCATTGTCACT GAGAACCACCAAATCTGACTTTTACATTTGGTCTCAGAATTTAGGTTCCTGCCCTGTTGGTTTTTTTTTTTTTTTTTTAA ACAGTTTTCAAAAGTTCTTAAAGGCAAGAGTGAATTTCTGTGGATTTTACTGGTCCCAGCTTTTAGGTTCTTTAAGACAC TAACAGGACTACATAGAGGCTTTTTCAGCATTACTGTGTCGTCTCCGTGCCAGATGTGGCAAGATCACCATTAGCAAATG GAAATTACATTTGAAAGCCATTAGACTTATAGGTGATGCAAGCATCTAAGAGAGAGGTTAATCACACTATAGAGGCATAA GTGGTATCAGTTTTCATTTTTCTAATTGTTTAAACTGTGTTTTATACCAGTGTTTGCAAGTAATTGGGTGTTAGCTTGAG ATGGTTAAAGGTGGTTTGGGGAGGGACTTCGTTGTAATGGTTTTGCTGTAAAAAATGTTTCCAACTCCGCTGAAATGTTG CTGAAAAGCATGGTGCTGGTAACAGTTCAACAATCCGTGGCTGCTCATTCTTGCCTACTTTACTCTCCCACTGAAGCAGG TTAGCGTTGAAGGTGGTATGGAAAAGCCTGCATGCCTGTTCAATTCTTTTGTTTCTTCTCCTTCCCCCTCCCCCTACCTC CTTCCCCTCACTCCTCCCCTCCTTCGCTCGCTCAACCTCTTTTGTTCAGTATGTGTAACTTGAAGCTAATTTGTACTACT GGATATCTGACTGGAGCCACAGATACAGAATCTGTATTGTTCTTACTGAAACACAGCATGGAATTAACATTAAACTTAAA TAAAACAAACCTAAATT

Codon usage

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

M

D

D

R

E

D

L

V

Y

Q

A

K

L

A

E

CGG

ATT

GAG

GCG

CCG

CCA

TTT

TTG

CTG

CCC

GGA

CGC

GGA

GCG

AGA

16

17

18

19

20

21

22

23

24

25

26

27

28

29

30

Q

A

E

R

Y

D

E

M

V

E

S

M

K

K

V

GGC

TGA

GAG

AGT

CGG

AGA

CAC

TAT

CCG

CTT

CCA

TCC

GTC

GCG

CAG

31

32

33

34

35

36

37

38

39

40

41

42

43

44

45

A

G

M

D

V

E

L

T

V

E

E

R

N

L

L

ACC

CTG

CCG

GAG

CCG

CTG

CCG

CTA

TGG

ATG

ATC

GAG

AGG

ATC

TGG

46

47

48

49

50

51

52

53

54

55

56

57

58

59

60

S

V

A

Y

K

N

V

I

G

A

R

R

A

S

W

TGT

ACC

AGG

CGA

AGC

TGG

CCG

AGC

AGG

CTG

AGC

GAT

ACG

ACG

AAA

61

62

63

64

65

66

67

68

69

70

71

72

73

74

75

R

I

I

S

S

I

E

Q

K

E

E

N

K

G

G

TGG

TGG

AGT

CAA

TGA

AGA

AAG

TAG

CAG

GGA

TGG

ATG

TGG

AGC

TGA

76

77

78

79

80

81

82

83

84

85

86

87

88

89

90

E

D

K

L

K

M

I

R

E

Y

R

Q

M

V

E

CAG

TTG

AAG

AAA

GAA

ACC

TCC

TAT

CTG

TTG

CAT

ATA

AGA

ATG

TGA

91

92

93

94

95

96

97

98

99

100

101

102

103

104

105

T

E

L

K

L

I

C

C

D

I

L

D

V

L

D

TTG

GAG

CTA

GAA

GAG

CCT

CCT

GGA

GAA

TAA

TCA

GCA

GCA

TTG

AAC

106

107

108

109

110

111

112

113

114

115

116

117

118

119

120

K

H

L

I

P

A

A

N

T

G

E

S

K

V

F

AGA

AAG

AAG

AAA

ACA

AGG

GAG

GAG

AAG

ACA

AGC

TAA

AAA

TGA

TTC

121

122

123

124

125

126

127

128

129

130

131

132

133

134

135

Y

Y

K

M

K

G

D

Y

H

R

Y

L

A

E

F

GGG

AAT

ATC

GGC

AAA

TGG

TTG

AGA

CTG

AGC

TAA

AGT

TAA

TCT

GTT

136

137

138

139

140

141

142

143

144

145

146

147

148

149

150

A

T

G

N

D

R

K

E

A

A

E

N

S

L

V

GTG

ACA

TTC

TGG

ATG

TAC

TGG

ACA

AAC

ACC

TCA

TTC

CAG

CAG

CTA

151

152

153

154

155

156

157

158

159

160

161

162

163

164

165

A

Y

K

A

A

S

D

I

A

M

T

E

L

P

P

ACA

CTG

GCG

AGT

CCA

AGG

TTT

TCT

ATT

ATA

AAA

TGA

AAG

GGG

ACT

166

167

168

169

170

171

172

173

174

175

176

177

178

179

180

T

H

P

I

R

L

G

L

A

L

N

F

S

V

F

ACC

ACA

GGT

ATC

TGG

CAG

AAT

TTG

CCA

CAG

GAA

ACG

ACA

GGA

AGG

181

182

183

184

185

186

187

188

189

190

191

192

193

194

195

Y

Y

E

I

L

N

S

P

D

R

A

C

R

L

A

AGG

CTG

CGG

AGA

ACA

GCC

TAG

TGG

CTT

ATA

AAG

CTG

CTA

GTG

ATA

196

197

198

199

200

201

202

203

204

205

206

207

208

209

210

K

A

A

F

D

D

A

I

A

E

L

D

T

L

S

TTG

CAA

TGA

CAG

AAC

TTC

CAC

CAA

CGC

ATC

CTA

TTC

GCT

TAG

GTC

211

212

213

214

215

216

217

218

219

220

221

222

223

224

225

E

E

S

Y

K

D

S

T

L

I

M

Q

L

L

R

TTG

CTC

TCA

ATT

TTT

CCG

TAT

TCT

ACT

ACG

AAA

TTC

TTA

ATT

CCC

226

227

228

229

230

231

232

233

234

235

236

237

238

239

240

D

N

L

T

L

W

T

S

D

M

Q

G

D

G

E

CTG

ACC

GTG

CCT

GCA

GGT

TGG

CAA

AAG

CAG

CTT

TTG

ATG

ATG

CAA

241

242

243

244

245

246

247

248

249

250

251

252

253

254

255

E

Q

N

K

E

A

L

Q

D

V

E

D

E

N

Q

TTG

CAG

AAC

TGG

ATA

CGC

TGA

GTG

AAG

AAA

GCT

ATA

AGG

ACT

CTA

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