Integrated annotated Human normal Protein (IHP) Browser
Detalied information of IHP
Name
ENSP00000293780
Comment
Origin of IHP
|
Gene Origins
|
Interpro Annotation
IPR002394 (12.00): Nicotinic acetylcholine receptor (58~73) (92~105) (110~121) (128~146)
IPR006029 (12.00): Neurotransmitter-gated ion-channel transmembrane region (247~474)
IPR006201 (12.00): Neurotransmitter-gated ion-channel (9~103) (104~147) (148~233) (234~491)
IPR006202 (12.00): Neurotransmitter-gated ion-channel ligand-binding (22~240)
IPR002394 (18.00): Nicotinic acetylcholine receptor, N-terminal (58~73) (92~105) (110~121) (128~146)
IPR006029 (18.00): Neurotransmitter-gated ion-channel transmembrane region (240~485)
IPR006201 (18.00): Neurotransmitter-gated ion-channel (41~103) (104~147) (148~233) (234~483)
IPR006202 (18.00): Neurotransmitter-gated ion-channel ligand-binding (22~245)
noIPR (18.00): (41~483)
19 Mutated sequence(s)
| Name | Length (aa) | Type |
| IMS000006 | 59 | Deletion |
| IMS018918 | 83 | |
| IMS017164 | 493 | Point |
| IMS017167 | 493 | Point |
| IMS085062 | 493 | Point |
| IMS017166 | 493 | Point |
| IMS063247 | 499 | Insertion |
| IMS069584 | 493 | Point |
| IMS085063 | 493 | Point |
| IMS085064 | 493 | Point |
| IMS085065 | 493 | Point |
| IMS085066 | 493 | Point |
| IMS085067 | 493 | Point |
| IMS149854 | 493 | Point |
| IMS063245 | 499 | Point ,Insertion |
| IMS063246 | 493 | Point |
| IMS017165 | 493 | Point |
| IMS085061 | 493 | Point |
| IMS085060 | 493 | Point |
Amino acid length
493 aa
Amino acid sequence viewer
| |......10|.......20|.......30|.......40|.......50|.......60|.......70|.......80| | |
| + 1 81 161 241 321 401 481 |
MARAPLGVLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDW QDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQ NCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKP LFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVM NCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRH RQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGAYFN RVPDLPYAPCIQP |
cDNA sequence length
2463 bp
cDNA sequence viewer
| |......10|.......20|.......30|.......40|.......50|.......60|.......70|.......80| | |
| + 1 81 161 241 321 401 481 561 641 721 801 881 961 1041 1121 1201 1281 1361 1441 1521 1601 1681 1761 1841 1921 2001 2081 2161 2241 2321 2401 |
CACGCAGCAGGATGGCAAGGGCTCCGCTTGGGGTCCTGCTCCTCTTGGGGCTTCTCGGCAGGGGTGTGGGGAAGAACGAG GAACTGCGTCTTTATCACCATCTCTTCAACAACTATGACCCAGGAAGCCGGCCAGTGCGGGAGCCTGAGGATACTGTCAC CATCAGCCTCAAGGTCACCCTGACGAATCTCATCTCACTGAATGAAAAAGAGGAGACTCTCACCACTAGCGTCTGGATTG GAATCGATTGGCAGGATTACCGACTCAACTACAGCAAGGACGACTTTGGGGGTATAGAAACCCTGCGAGTCCCTTCAGAA CTCGTGTGGCTGCCAGAGATTGTGCTGGAAAACAATATTGATGGCCAGTTCGGAGTGGCCTACGACGCCAACGTGCTCGT CTACGAGGGCGGCTCCGTGACGTGGCTGCCTCCGGCCATCTACCGCAGCGTCTGCGCAGTGGAGGTCACCTACTTCCCCT TCGATTGGCAGAACTGTTCGCTTATTTTCCGCTCTCAGACGTACAATGCCGAAGAGGTGGAGTTCACTTTTGCCGTAGAC AACGACGGCAAGACCATCAACAAGATCGACATCGACACAGAGGCCTATACTGAGAACGGCGAGTGGGCCATCGACTTCTG CCCGGGGGTGATCCGCCGCCACCACGGTGGCGCCACCGACGGCCCAGGGGAGACTGACGTCATCTACTCGCTCATCATCC GCCGGAAGCCGCTCTTCTACGTCATTAACATCATCGTGCCCTGTGTGCTCATCTCGGGCCTGGTGCTGCTCGCCTACTTC CTGCCGGCGCAGGCCGGCGGCCAGAAATGCACGGTCTCCATCAACGTCCTGCTCGCCCAGACCGTCTTCTTGTTCCTCAT TGCCCAGAAAATCCCAGAGACTTCTCTGAGCGTGCCGCTCCTGGGCAGGTTCCTTATTTTCGTCATGGTGGTCGCCACGC TCATTGTCATGAATTGCGTCATCGTGCTCAACGTGTCCCAGCGGACGCCCACCACCCACGCCATGTCCCCGCGGCTGCGC CACGTTCTCCTGGAGCTGCTGCCGCGCCTCCTGGGCTCCCCGCCGCCGCCCGAGGCCCCCCGGGCCGCCTCGCCCCCAAG GCGGGCGTCGTCGGTGGGCTTATTGCTCCGCGCGGAGGAGCTGATACTGAAAAAGCCACGGAGCGAGCTCGTGTTTGAGG GGCAGAGGCACCGGCAGGGGACCTGGACGGCTGCCTTCTGCCAGAGCCTGGGCGCCGCCGCCCCCGAGGTCCGCTGCTGT GTGGATGCCGTGAACTTCGTGGCCGAGAGCACGAGAGATCAGGAGGCCACCGGCGAGGAAGTGTCCGACTGGGTGCGCAT GGGGAATGCCCTTGACAACATCTGCTTCTGGGCCGCTCTGGTGCTCTTCAGCGTGGGCTCCAGCCTCATCTTCCTCGGGG CCTACTTCAACCGAGTGCCTGATCTCCCCTACGCGCCGTGTATCCAGCCTTAGCTCGCACCGACTTCAATTTCCCACCCA TCTCCAGTAGGAAATTGATTTTGAAAAAGTAGGCTGCCGCCACCACGGCATTATGATCCCTTCCCCCTGCTGATCAATCT GCAGTTTGTGAACTTCACAAGAATGGTGTGTGCCCGTTCCCTGGCGTGTGTAGGCCTGGCCGCAGTCCAGGGGTCAGCAG GAGGAAAGGGTTCACATAGGCTCTCAGGTGCCAGTCTTCCAGAAAGCAAGGACTGCCCTTCATTCAGCCTTGCTGACCTC CCAGCCTTTCTAAGGCTCAGCCCCACGGGACTCTGGTGGCTGCCAGCTTGTGAGCTATCTATCTATATTCATTTCATAGC CAAACAGGAGACCCCTTTGCAGGACTTGCACACAGGGAGGCTGTAGCCAGGAAACCCTCTTCTTCCCTGGTCTGGCTCTG CTGGAGCGGGTGGGAACCAAACACCTTCAGTGCTGGTGGCCCTCAGGCCCACAGGTTTAAGGCTGAGGCTGCCCTGACCC TTCCACAGTCATTTCTTCTAGGTTTTCTTGGCCCAGCACTGCCCATCCCACCCCATGAGGCTCACTCATTGCAGATCCCA GCCCACCCTGCCCCTTTCTTCCCCACCCTGGAGGCTCTCTCTGCCTAGTCTACAGTACTGACAGAAAGCAAGGACATGCG GCCTGCATGGTGGGAGCTGGTTGAATTGTCTTTATTAACAAACAGGATATCCAAGGCCACTACATTGAGGAGGGGGGAGG GGGGAGGGAGGAGAAGGGTTACTTGCTGCTCACACTATATACAGATGCAAGCAAGGGGCGTGGAGAGTGAGGGCTCCCTG CTCCCTCCCTCCACCGGGGAAGGGCATGGGCTAGAAGAGGAGAGGGGGGTCGGGAATGGGGGGAATGTTTTGGCTGGCGG GGTCCCCCCTCCATTCCCTGGAGTTTGGGGGAAGGGGAATCATTAAAGTGCTTTCAGAAAATG |
Codon usage
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| M | A | R | A | P | L | G | V | L | L | L | L | G | L | L |
| CAC | GCA | GCA | GGA | TGG | CAA | GGG | CTC | CGC | TTG | GGG | TCC | TGC | TCC | TCT |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| G | R | G | V | G | K | N | E | E | L | R | L | Y | H | H |
| TGG | GGC | TTC | TCG | GCA | GGG | GTG | TGG | GGA | AGA | ACG | AGG | AAC | TGC | GTC |
| 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 |
| L | F | N | N | Y | D | P | G | S | R | P | V | R | E | P |
| TTT | ATC | ACC | ATC | TCT | TCA | ACA | ACT | ATG | ACC | CAG | GAA | GCC | GGC | CAG |
| 46 | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 |
| E | D | T | V | T | I | S | L | K | V | T | L | T | N | L |
| TGC | GGG | AGC | CTG | AGG | ATA | CTG | TCA | CCA | TCA | GCC | TCA | AGG | TCA | CCC |
| 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 |
| I | S | L | N | E | K | E | E | T | L | T | T | S | V | W |
| TGA | CGA | ATC | TCA | TCT | CAC | TGA | ATG | AAA | AAG | AGG | AGA | CTC | TCA | CCA |
| 76 | 77 | 78 | 79 | 80 | 81 | 82 | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 |
| I | G | I | D | W | Q | D | Y | R | L | N | Y | S | K | D |
| CTA | GCG | TCT | GGA | TTG | GAA | TCG | ATT | GGC | AGG | ATT | ACC | GAC | TCA | ACT |
| 91 | 92 | 93 | 94 | 95 | 96 | 97 | 98 | 99 | 100 | 101 | 102 | 103 | 104 | 105 |
| D | F | G | G | I | E | T | L | R | V | P | S | E | L | V |
| ACA | GCA | AGG | ACG | ACT | TTG | GGG | GTA | TAG | AAA | CCC | TGC | GAG | TCC | CTT |
| 106 | 107 | 108 | 109 | 110 | 111 | 112 | 113 | 114 | 115 | 116 | 117 | 118 | 119 | 120 |
| W | L | P | E | I | V | L | E | N | N | I | D | G | Q | F |
| CAG | AAC | TCG | TGT | GGC | TGC | CAG | AGA | TTG | TGC | TGG | AAA | ACA | ATA | TTG |
| 121 | 122 | 123 | 124 | 125 | 126 | 127 | 128 | 129 | 130 | 131 | 132 | 133 | 134 | 135 |
| G | V | A | Y | D | A | N | V | L | V | Y | E | G | G | S |
| ATG | GCC | AGT | TCG | GAG | TGG | CCT | ACG | ACG | CCA | ACG | TGC | TCG | TCT | ACG |
| 136 | 137 | 138 | 139 | 140 | 141 | 142 | 143 | 144 | 145 | 146 | 147 | 148 | 149 | 150 |
| V | T | W | L | P | P | A | I | Y | R | S | V | C | A | V |
| AGG | GCG | GCT | CCG | TGA | CGT | GGC | TGC | CTC | CGG | CCA | TCT | ACC | GCA | GCG |
| 151 | 152 | 153 | 154 | 155 | 156 | 157 | 158 | 159 | 160 | 161 | 162 | 163 | 164 | 165 |
| E | V | T | Y | F | P | F | D | W | Q | N | C | S | L | I |
| TCT | GCG | CAG | TGG | AGG | TCA | CCT | ACT | TCC | CCT | TCG | ATT | GGC | AGA | ACT |
| 166 | 167 | 168 | 169 | 170 | 171 | 172 | 173 | 174 | 175 | 176 | 177 | 178 | 179 | 180 |
| F | R | S | Q | T | Y | N | A | E | E | V | E | F | T | F |
| GTT | CGC | TTA | TTT | TCC | GCT | CTC | AGA | CGT | ACA | ATG | CCG | AAG | AGG | TGG |
| 181 | 182 | 183 | 184 | 185 | 186 | 187 | 188 | 189 | 190 | 191 | 192 | 193 | 194 | 195 |
| A | V | D | N | D | G | K | T | I | N | K | I | D | I | D |
| AGT | TCA | CTT | TTG | CCG | TAG | ACA | ACG | ACG | GCA | AGA | CCA | TCA | ACA | AGA |
| 196 | 197 | 198 | 199 | 200 | 201 | 202 | 203 | 204 | 205 | 206 | 207 | 208 | 209 | 210 |
| T | E | A | Y | T | E | N | G | E | W | A | I | D | F | C |
| TCG | ACA | TCG | ACA | CAG | AGG | CCT | ATA | CTG | AGA | ACG | GCG | AGT | GGG | CCA |
| 211 | 212 | 213 | 214 | 215 | 216 | 217 | 218 | 219 | 220 | 221 | 222 | 223 | 224 | 225 |
| P | G | V | I | R | R | H | H | G | G | A | T | D | G | P |
| TCG | ACT | TCT | GCC | CGG | GGG | TGA | TCC | GCC | GCC | ACC | ACG | GTG | GCG | CCA |
| 226 | 227 | 228 | 229 | 230 | 231 | 232 | 233 | 234 | 235 | 236 | 237 | 238 | 239 | 240 |
| G | E | T | D | V | I | Y | S | L | I | I | R | R | K | P |
| CCG | ACG | GCC | CAG | GGG | AGA | CTG | ACG | TCA | TCT | ACT | CGC | TCA | TCA | TCC |
| 241 | 242 | 243 | 244 | 245 | 246 | 247 | 248 | 249 | 250 | 251 | 252 | 253 | 254 | 255 |
| L | F | Y | V | I | N | I | I | V | P | C | V | L | I | S |
| GCC | GGA | AGC | CGC | TCT | TCT | ACG | TCA | TTA | ACA | TCA | TCG | TGC | CCT | GTG |
| 256 | 257 | 258 | 259 | 260 | 261 | 262 | 263 | 264 | 265 | 266 | 267 | 268 | 269 | 270 |
| G | L | V | L | L | A | Y | F | L | P | A | Q | A | G | G |
| TGC | TCA | TCT | CGG | GCC | TGG | TGC | TGC | TCG | CCT | ACT | TCC | TGC | CGG | CGC |
| 271 | 272 | 273 | 274 | 275 | 276 | 277 | 278 | 279 | 280 | 281 | 282 | 283 | 284 | 285 |
| Q | K | C | T | V | S | I | N | V | L | L | A | Q | T | V |
| AGG | CCG | GCG | GCC | AGA | AAT | GCA | CGG | TCT | CCA | TCA | ACG | TCC | TGC | TCG |
| 286 | 287 | 288 | 289 | 290 | 291 | 292 | 293 | 294 | 295 | 296 | 297 | 298 | 299 | 300 |
| F | L | F | L | I | A | Q | K | I | P | E | T | S | L | S |
| CCC | AGA | CCG | TCT | TCT | TGT | TCC | TCA | TTG | CCC | AGA | AAA | TCC | CAG | AGA |
| 301 | 302 | 303 | 304 | 305 | 306 | 307 | 308 | 309 | 310 | 311 | 312 | 313 | 314 | 315 |
| V | P | L | L | G | R | F | L | I | F | V | M | V | V | A |
| CTT | CTC | TGA | GCG | TGC | CGC | TCC | TGG | GCA | GGT | TCC | TTA | TTT | TCG | TCA |
| 316 | 317 | 318 | 319 | 320 | 321 | 322 | 323 | 324 | 325 | 326 | 327 | 328 | 329 | 330 |
| T | L | I | V | M | N | C | V | I | V | L | N | V | S | Q |
| TGG | TGG | TCG | CCA | CGC | TCA | TTG | TCA | TGA | ATT | GCG | TCA | TCG | TGC | TCA |
| 331 | 332 | 333 | 334 | 335 | 336 | 337 | 338 | 339 | 340 | 341 | 342 | 343 | 344 | 345 |
| R | T | P | T | T | H | A | M | S | P | R | L | R | H | V |
| ACG | TGT | CCC | AGC | GGA | CGC | CCA | CCA | CCC | ACG | CCA | TGT | CCC | CGC | GGC |
| 346 | 347 | 348 | 349 | 350 | 351 | 352 | 353 | 354 | 355 | 356 | 357 | 358 | 359 | 360 |
| L | L | E | L | L | P | R | L | L | G | S | P | P | P | P |
| TGC | GCC | ACG | TTC | TCC | TGG | AGC | TGC | TGC | CGC | GCC | TCC | TGG | GCT | CCC |
| 361 | 362 | 363 | 364 | 365 | 366 | 367 | 368 | 369 | 370 | 371 | 372 | 373 | 374 | 375 |
| E | A | P | R | A | A | S | P | P | R | R | A | S | S | V |
| CGC | CGC | CGC | CCG | AGG | CCC | CCC | GGG | CCG | CCT | CGC | CCC | CAA | GGC | GGG |
| 376 | 377 | 378 | 379 | 380 | 381 | 382 | 383 | 384 | 385 | 386 | 387 | 388 | 389 | 390 |
| G | L | L | L | R | A | E | E | L | I | L | K | K | P | R |
| CGT | CGT | CGG | TGG | GCT | TAT | TGC | TCC | GCG | CGG | AGG | AGC | TGA | TAC | TGA |
| 391 | 392 | 393 | 394 | 395 | 396 | 397 | 398 | 399 | 400 | 401 | 402 | 403 | 404 | 405 |
| S | E | L | V | F | E | G | Q | R | H | R | Q | G | T | W |
| AAA | AGC | CAC | GGA | GCG | AGC | TCG | TGT | TTG | AGG | GGC | AGA | GGC | ACC | GGC |
| 406 | 407 | 408 | 409 | 410 | 411 | 412 | 413 | 414 | 415 | 416 | 417 | 418 | 419 | 420 |
| T | A | A | F | C | Q | S | L | G | A | A | A | P | E | V |
| AGG | GGA | CCT | GGA | CGG | CTG | CCT | TCT | GCC | AGA | GCC | TGG | GCG | CCG | CCG |
| 421 | 422 | 423 | 424 | 425 | 426 | 427 | 428 | 429 | 430 | 431 | 432 | 433 | 434 | 435 |
| R | C | C | V | D | A | V | N | F | V | A | E | S | T | R |
| CCC | CCG | AGG | TCC | GCT | GCT | GTG | TGG | ATG | CCG | TGA | ACT | TCG | TGG | CCG |
| 436 | 437 | 438 | 439 | 440 | 441 | 442 | 443 | 444 | 445 | 446 | 447 | 448 | 449 | 450 |
| D | Q | E | A | T | G | E | E | V | S | D | W | V | R | M |
| AGA | GCA | CGA | GAG | ATC | AGG | AGG | CCA | CCG | GCG | AGG | AAG | TGT | CCG | ACT |
| 451 | 452 | 453 | 454 | 455 | 456 | 457 | 458 | 459 | 460 | 461 | 462 | 463 | 464 | 465 |
| G | N | A | L | D | N | I | C | F | W | A | A | L | V | L |
| GGG | TGC | GCA | TGG | GGA | ATG | CCC | TTG | ACA | ACA | TCT | GCT | TCT | GGG | CCG |
| 466 | 467 | 468 | 469 | 470 | 471 | 472 | 473 | 474 | 475 | 476 | 477 | 478 | 479 | 480 |
| F | S | V | G | S | S | L | I | F | L | G | A | Y | F | N |
| CTC | TGG | TGC | TCT | TCA | GCG | TGG | GCT | CCA | GCC | TCA | TCT | TCC | TCG | GGG |
| 481 | 482 | 483 | 484 | 485 | 486 | 487 | 488 | 489 | 490 | 491 | 492 | 493 | ||
| R | V | P | D | L | P | Y | A | P | C | I | Q | P | ||
| CCT | ACT | TCA | ACC | GAG | TGC | CTG | ATC | TCC | CCT | ACG | CGC | CGT |
