Integrated annotated Human normal Protein (IHP) Browser
Detalied information of IHP
Name
ENSP00000304290
Comment
Origin of IHP
|
Gene Origins
|
Interpro Annotation
IPR002394 (12.00): Nicotinic acetylcholine receptor (61~76) (95~108) (113~124) (131~149)
IPR006029 (12.00): Neurotransmitter-gated ion-channel transmembrane region (252~487)
IPR006201 (12.00): Neurotransmitter-gated ion-channel (1~106) (107~150) (151~238) (239~501)
IPR006202 (12.00): Neurotransmitter-gated ion-channel ligand-binding (25~245)
IPR002394 (18.00): Nicotinic acetylcholine receptor, N-terminal (131~149) (113~124) (95~108) (61~76)
IPR006029 (18.00): Neurotransmitter-gated ion-channel transmembrane region (245~498)
IPR006201 (18.00): Neurotransmitter-gated ion-channel (239~496) (151~238) (107~150) (1~106)
IPR006202 (18.00): Neurotransmitter-gated ion-channel ligand-binding (25~250)
noIPR (18.00): (44~496)
16 Mutated sequence(s)
| Name | Length (aa) | Type |
| IMS000004 | 501 | Point |
| IMS017161 | 501 | Point |
| IMS069582 | 501 | Point |
| IMS069585 | 498 | Deletion |
| IMS069586 | 499 | Deletion |
| IMS069587 | 497 | Deletion |
| IMS069588 | 495 | Deletion |
| IMS069589 | 501 | Others |
| IMS069590 | 501 | Others |
| IMS085049 | 501 | Point |
| IMS085050 | 501 | Point |
| IMS185028 | 501 | Point |
| IMS185030 | 501 | Point |
| IMS185029 | 501 | Point |
| IMS085048 | 501 | Point |
| IMS000005 | 13 | Deletion |
Amino acid length
501 aa
Amino acid sequence viewer
| |......10|.......20|.......30|.......40|.......50|.......60|.......70|.......80| | |
| + 1 81 161 241 321 401 481 |
MTPGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLD LEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPF DWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLI IRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVT FSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPKPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFL FPKPNRFQPELSAPDLRRFIDGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTS VGTLVIFLDATYHLPPPDPFP |
cDNA sequence length
2437 bp
cDNA sequence viewer
| |......10|.......20|.......30|.......40|.......50|.......60|.......70|.......80| | |
| + 1 81 161 241 321 401 481 561 641 721 801 881 961 1041 1121 1201 1281 1361 1441 1521 1601 1681 1761 1841 1921 2001 2081 2161 2241 2321 2401 |
AGCGGCTCTCTGAGCGAAGTCACTGAGCGAGCCGCCAGGCTATGACCCCAGGGGCTCTGCTGATGCTGCTGGGGGCGCTG GGGGCGCCGCTCGCCCCAGGCGTCCGCGGCTCGGAGGCGGAGGGTCGACTCCGGGAGAAACTTTTCTCTGGCTATGATAG CTCCGTGCGGCCAGCGCGGGAGGTGGGAGACCGTGTCAGGGTCAGCGTTGGTCTCATCCTGGCGCAACTCATCAGCCTGA ACGAGAAGGATGAAGAGATGAGCACAAAGGTGTACTTAGACCTGGAGTGGACTGACTACAGGCTGAGCTGGGACCCTGCG GAGCACGACGGCATCGATTCGCTCCGCATCACGGCGGAATCCGTGTGGCTCCCTGACGTGGTGCTACTGAACAACAATGA TGGGAATTTTGACGTGGCTCTGGACATTAGCGTCGTGGTGTCCTCCGACGGCTCCGTGCGTTGGCAACCCCCGGGCATCT ATCGCAGCAGCTGCAGCATCCAGGTCACCTACTTCCCCTTCGACTGGCAGAATTGCACTATGGTGTTCAGCTCCTACAGC TACGACAGCTCGGAGGTCAGCCTGCAGACAGGCCTGGGTCCTGACGGGCAAGGGCATCAGGAAATCCACATTCATGAAGG GACTTTCATTGAGAATGGCCAGTGGGAGATTATCCACAAGCCCTCTCGGCTAATCCAGCCTCCAGGCGATCCTAGGGGAG GGAGGGAAGGACAGCGCCAGGAAGTCATCTTCTACCTCATCATCCGCCGCAAGCCTCTCTTCTACCTGGTCAACGTCATT GCCCCATGCATCCTCATCACTCTTCTGGCCATCTTCGTCTTCTACCTGCCACCAGATGCAGGAGAGAAGATGGGGCTCTC AATCTTTGCCCTGCTGACCCTTACTGTGTTCCTGCTGCTGCTGGCTGACAAAGTACCTGAGACCTCACTATCAGTACCCA TTATTATCAAGTACCTCATGTTTACCATGGTCCTCGTCACCTTCTCAGTCATCCTTAGTGTCGTGGTTCTCAACCTGCAC CACCGCTCACCCCACACCCACCAAATGCCCCTTTGGGTCCGTCAGATCTTCATTCACAAACTTCCGCTGTACCTGCGTCT AAAAAGGCCCAAACCCGAGAGAGACCTGATGCCGGAGCCCCCTCACTGTTCTTCTCCAGGAAGTGGCTGGGGTCGGGGAA CAGATGAATATTTCATCCGGAAGCCGCCAAGTGATTTTCTCTTCCCCAAACCCAATAGGTTCCAGCCTGAACTGTCTGCC CCTGATCTGCGGCGATTTATCGATGGTCCAAACCGGGCTGTGGCCCTGCTTCCGGAGCTACGGGAGGTCGTCTCCTCTAT CAGCTACATCGCTCGACAGCTGCAGGAACAGGAGGACCACGATGCGCTGAAGGAGGACTGGCAGTTTGTGGCCATGGTAG TGGACCGCCTCTTCCTGTGGACTTTCATCATCTTCACCAGCGTTGGGACCCTAGTCATCTTCCTGGACGCCACGTACCAC TTGCCCCCTCCAGACCCCTTTCCTTGAAGACTGGAGGGTTGAGACCCAGGCCCCCTGCCAGTTGAAGTGAGAGTTTGGTG ATACTGTCAAGCCCTATCCTTCTCTGCCTCTTAACTCCTTCACGAGGAATCTGGGCCTCTTATTTCGTTTCTGGGGACTG CATTGGACTGAGGGCTGGGTAGGCAGGTGTCTTGGACCCACCTGAAATGCAGTATCATCTGATTTACTCTTTGGGATCTT GAAGAAGCTCTTTTGGGTATCAACACCTAGGTCGCCAGTGAAATAGAACACAGAACAGGAACTAGATTATAAGCCTTATG AGGTCAAGAAATGTGACTTGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCGGAT CACCTGAGGTCGGGAGTTTGAGACCAGCCCGACCAACATGGAGAAACCCTGTCTCTACTAAAAATACAAAATTAGCCAGG TGTGGTGGTACATGCCTGTAATCCCAGCTACTAGGGAGGCTGAGGCAGGAGAATCACTCGAACCCGGGAGGCAGAGGTTG CAGTGAGTCAAGATCACGCCATTGCACTCCAGCCTGGGCAACAAGAGCGAAACTCCATCTCAAAAAAAAAAAAGTGTCTT GTTCACTGCAGCATGCCCAGTGCCACGCACAGGTGCTGACCTATAGTAAGTGCTTAACATTTGTTGAATAGGGGAAAGAA ATTTCCGGAAGTAAATACAGCAATTAATAATGTTTATAAGCTGGGCATGGTCGCTCAGGCCAGTAATCCCAGTGACTTAG GAGGCTGAGGTGGGAGGATTACTTGAAACCCACAGTTTGAGACCAGCCTGGGCAACATAGTGAGACCCTGTCTCTAAAAA AATAAAAATAGAAATAAAGTAGTGCTTATTGTTTGCA |
Codon usage
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| M | T | P | G | A | L | L | M | L | L | G | A | L | G | A |
| AGC | GGC | TCT | CTG | AGC | GAA | GTC | ACT | GAG | CGA | GCC | GCC | AGG | CTA | TGA |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| P | L | A | P | G | V | R | G | S | E | A | E | G | R | L |
| CCC | CAG | GGG | CTC | TGC | TGA | TGC | TGC | TGG | GGG | CGC | TGG | GGG | CGC | CGC |
| 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 |
| R | E | K | L | F | S | G | Y | D | S | S | V | R | P | A |
| TCG | CCC | CAG | GCG | TCC | GCG | GCT | CGG | AGG | CGG | AGG | GTC | GAC | TCC | GGG |
| 46 | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 |
| R | E | V | G | D | R | V | R | V | S | V | G | L | I | L |
| AGA | AAC | TTT | TCT | CTG | GCT | ATG | ATA | GCT | CCG | TGC | GGC | CAG | CGC | GGG |
| 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 |
| A | Q | L | I | S | L | N | E | K | D | E | E | M | S | T |
| AGG | TGG | GAG | ACC | GTG | TCA | GGG | TCA | GCG | TTG | GTC | TCA | TCC | TGG | CGC |
| 76 | 77 | 78 | 79 | 80 | 81 | 82 | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 |
| K | V | Y | L | D | L | E | W | T | D | Y | R | L | S | W |
| AAC | TCA | TCA | GCC | TGA | ACG | AGA | AGG | ATG | AAG | AGA | TGA | GCA | CAA | AGG |
| 91 | 92 | 93 | 94 | 95 | 96 | 97 | 98 | 99 | 100 | 101 | 102 | 103 | 104 | 105 |
| D | P | A | E | H | D | G | I | D | S | L | R | I | T | A |
| TGT | ACT | TAG | ACC | TGG | AGT | GGA | CTG | ACT | ACA | GGC | TGA | GCT | GGG | ACC |
| 106 | 107 | 108 | 109 | 110 | 111 | 112 | 113 | 114 | 115 | 116 | 117 | 118 | 119 | 120 |
| E | S | V | W | L | P | D | V | V | L | L | N | N | N | D |
| CTG | CGG | AGC | ACG | ACG | GCA | TCG | ATT | CGC | TCC | GCA | TCA | CGG | CGG | AAT |
| 121 | 122 | 123 | 124 | 125 | 126 | 127 | 128 | 129 | 130 | 131 | 132 | 133 | 134 | 135 |
| G | N | F | D | V | A | L | D | I | S | V | V | V | S | S |
| CCG | TGT | GGC | TCC | CTG | ACG | TGG | TGC | TAC | TGA | ACA | ACA | ATG | ATG | GGA |
| 136 | 137 | 138 | 139 | 140 | 141 | 142 | 143 | 144 | 145 | 146 | 147 | 148 | 149 | 150 |
| D | G | S | V | R | W | Q | P | P | G | I | Y | R | S | S |
| ATT | TTG | ACG | TGG | CTC | TGG | ACA | TTA | GCG | TCG | TGG | TGT | CCT | CCG | ACG |
| 151 | 152 | 153 | 154 | 155 | 156 | 157 | 158 | 159 | 160 | 161 | 162 | 163 | 164 | 165 |
| C | S | I | Q | V | T | Y | F | P | F | D | W | Q | N | C |
| GCT | CCG | TGC | GTT | GGC | AAC | CCC | CGG | GCA | TCT | ATC | GCA | GCA | GCT | GCA |
| 166 | 167 | 168 | 169 | 170 | 171 | 172 | 173 | 174 | 175 | 176 | 177 | 178 | 179 | 180 |
| T | M | V | F | S | S | Y | S | Y | D | S | S | E | V | S |
| GCA | TCC | AGG | TCA | CCT | ACT | TCC | CCT | TCG | ACT | GGC | AGA | ATT | GCA | CTA |
| 181 | 182 | 183 | 184 | 185 | 186 | 187 | 188 | 189 | 190 | 191 | 192 | 193 | 194 | 195 |
| L | Q | T | G | L | G | P | D | G | Q | G | H | Q | E | I |
| TGG | TGT | TCA | GCT | CCT | ACA | GCT | ACG | ACA | GCT | CGG | AGG | TCA | GCC | TGC |
| 196 | 197 | 198 | 199 | 200 | 201 | 202 | 203 | 204 | 205 | 206 | 207 | 208 | 209 | 210 |
| H | I | H | E | G | T | F | I | E | N | G | Q | W | E | I |
| AGA | CAG | GCC | TGG | GTC | CTG | ACG | GGC | AAG | GGC | ATC | AGG | AAA | TCC | ACA |
| 211 | 212 | 213 | 214 | 215 | 216 | 217 | 218 | 219 | 220 | 221 | 222 | 223 | 224 | 225 |
| I | H | K | P | S | R | L | I | Q | P | P | G | D | P | R |
| TTC | ATG | AAG | GGA | CTT | TCA | TTG | AGA | ATG | GCC | AGT | GGG | AGA | TTA | TCC |
| 226 | 227 | 228 | 229 | 230 | 231 | 232 | 233 | 234 | 235 | 236 | 237 | 238 | 239 | 240 |
| G | G | R | E | G | Q | R | Q | E | V | I | F | Y | L | I |
| ACA | AGC | CCT | CTC | GGC | TAA | TCC | AGC | CTC | CAG | GCG | ATC | CTA | GGG | GAG |
| 241 | 242 | 243 | 244 | 245 | 246 | 247 | 248 | 249 | 250 | 251 | 252 | 253 | 254 | 255 |
| I | R | R | K | P | L | F | Y | L | V | N | V | I | A | P |
| GGA | GGG | AAG | GAC | AGC | GCC | AGG | AAG | TCA | TCT | TCT | ACC | TCA | TCA | TCC |
| 256 | 257 | 258 | 259 | 260 | 261 | 262 | 263 | 264 | 265 | 266 | 267 | 268 | 269 | 270 |
| C | I | L | I | T | L | L | A | I | F | V | F | Y | L | P |
| GCC | GCA | AGC | CTC | TCT | TCT | ACC | TGG | TCA | ACG | TCA | TTG | CCC | CAT | GCA |
| 271 | 272 | 273 | 274 | 275 | 276 | 277 | 278 | 279 | 280 | 281 | 282 | 283 | 284 | 285 |
| P | D | A | G | E | K | M | G | L | S | I | F | A | L | L |
| TCC | TCA | TCA | CTC | TTC | TGG | CCA | TCT | TCG | TCT | TCT | ACC | TGC | CAC | CAG |
| 286 | 287 | 288 | 289 | 290 | 291 | 292 | 293 | 294 | 295 | 296 | 297 | 298 | 299 | 300 |
| T | L | T | V | F | L | L | L | L | A | D | K | V | P | E |
| ATG | CAG | GAG | AGA | AGA | TGG | GGC | TCT | CAA | TCT | TTG | CCC | TGC | TGA | CCC |
| 301 | 302 | 303 | 304 | 305 | 306 | 307 | 308 | 309 | 310 | 311 | 312 | 313 | 314 | 315 |
| T | S | L | S | V | P | I | I | I | K | Y | L | M | F | T |
| TTA | CTG | TGT | TCC | TGC | TGC | TGC | TGG | CTG | ACA | AAG | TAC | CTG | AGA | CCT |
| 316 | 317 | 318 | 319 | 320 | 321 | 322 | 323 | 324 | 325 | 326 | 327 | 328 | 329 | 330 |
| M | V | L | V | T | F | S | V | I | L | S | V | V | V | L |
| CAC | TAT | CAG | TAC | CCA | TTA | TTA | TCA | AGT | ACC | TCA | TGT | TTA | CCA | TGG |
| 331 | 332 | 333 | 334 | 335 | 336 | 337 | 338 | 339 | 340 | 341 | 342 | 343 | 344 | 345 |
| N | L | H | H | R | S | P | H | T | H | Q | M | P | L | W |
| TCC | TCG | TCA | CCT | TCT | CAG | TCA | TCC | TTA | GTG | TCG | TGG | TTC | TCA | ACC |
| 346 | 347 | 348 | 349 | 350 | 351 | 352 | 353 | 354 | 355 | 356 | 357 | 358 | 359 | 360 |
| V | R | Q | I | F | I | H | K | L | P | L | Y | L | R | L |
| TGC | ACC | ACC | GCT | CAC | CCC | ACA | CCC | ACC | AAA | TGC | CCC | TTT | GGG | TCC |
| 361 | 362 | 363 | 364 | 365 | 366 | 367 | 368 | 369 | 370 | 371 | 372 | 373 | 374 | 375 |
| K | R | P | K | P | E | R | D | L | M | P | E | P | P | H |
| GTC | AGA | TCT | TCA | TTC | ACA | AAC | TTC | CGC | TGT | ACC | TGC | GTC | TAA | AAA |
| 376 | 377 | 378 | 379 | 380 | 381 | 382 | 383 | 384 | 385 | 386 | 387 | 388 | 389 | 390 |
| C | S | S | P | G | S | G | W | G | R | G | T | D | E | Y |
| GGC | CCA | AAC | CCG | AGA | GAG | ACC | TGA | TGC | CGG | AGC | CCC | CTC | ACT | GTT |
| 391 | 392 | 393 | 394 | 395 | 396 | 397 | 398 | 399 | 400 | 401 | 402 | 403 | 404 | 405 |
| F | I | R | K | P | P | S | D | F | L | F | P | K | P | N |
| CTT | CTC | CAG | GAA | GTG | GCT | GGG | GTC | GGG | GAA | CAG | ATG | AAT | ATT | TCA |
| 406 | 407 | 408 | 409 | 410 | 411 | 412 | 413 | 414 | 415 | 416 | 417 | 418 | 419 | 420 |
| R | F | Q | P | E | L | S | A | P | D | L | R | R | F | I |
| TCC | GGA | AGC | CGC | CAA | GTG | ATT | TTC | TCT | TCC | CCA | AAC | CCA | ATA | GGT |
| 421 | 422 | 423 | 424 | 425 | 426 | 427 | 428 | 429 | 430 | 431 | 432 | 433 | 434 | 435 |
| D | G | P | N | R | A | V | A | L | L | P | E | L | R | E |
| TCC | AGC | CTG | AAC | TGT | CTG | CCC | CTG | ATC | TGC | GGC | GAT | TTA | TCG | ATG |
| 436 | 437 | 438 | 439 | 440 | 441 | 442 | 443 | 444 | 445 | 446 | 447 | 448 | 449 | 450 |
| V | V | S | S | I | S | Y | I | A | R | Q | L | Q | E | Q |
| GTC | CAA | ACC | GGG | CTG | TGG | CCC | TGC | TTC | CGG | AGC | TAC | GGG | AGG | TCG |
| 451 | 452 | 453 | 454 | 455 | 456 | 457 | 458 | 459 | 460 | 461 | 462 | 463 | 464 | 465 |
| E | D | H | D | A | L | K | E | D | W | Q | F | V | A | M |
| TCT | CCT | CTA | TCA | GCT | ACA | TCG | CTC | GAC | AGC | TGC | AGG | AAC | AGG | AGG |
| 466 | 467 | 468 | 469 | 470 | 471 | 472 | 473 | 474 | 475 | 476 | 477 | 478 | 479 | 480 |
| V | V | D | R | L | F | L | W | T | F | I | I | F | T | S |
| ACC | ACG | ATG | CGC | TGA | AGG | AGG | ACT | GGC | AGT | TTG | TGG | CCA | TGG | TAG |
| 481 | 482 | 483 | 484 | 485 | 486 | 487 | 488 | 489 | 490 | 491 | 492 | 493 | 494 | 495 |
| V | G | T | L | V | I | F | L | D | A | T | Y | H | L | P |
| TGG | ACC | GCC | TCT | TCC | TGT | GGA | CTT | TCA | TCA | TCT | TCA | CCA | GCG | TTG |
| 496 | 497 | 498 | 499 | 500 | 501 | |||||||||
| P | P | D | P | F | P | |||||||||
| GGA | CCC | TAG | TCA | TCT | TCC |
